Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | C5 | P01031 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | MAP2 | P11137 | 4/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170699 | 0.90 | MAP2 (0.41) | PTGS2MEN1KMT2AMAPTABCC4 | |
| SCHEMBL6172849 | 0.90 | ALDH1A1 (0.42) | PTGS2MEN1KMT2AMAPTABCC4 | |
| SCHEMBL6169060 | 0.89 | GPR17 (0.44) | PTGS2MEN1KMT2AMAPTABCC4 | |
| SCHEMBL6170210 | 0.88 | MAP2 (0.46) | PTGS2MEN1KMT2AMAPTABCC4 | |
| SCHEMBL6169573 | 0.86 | MEN1 (0.46) | PTGS2MEN1KMT2AMAP2CNR1 | |
| SCHEMBL6170675 | 0.84 | MAP2 (0.44) | PTGS2MEN1KMT2AMAPTABCC4 | |
| SCHEMBL6173696 | 0.83 | GPR17 (0.41) | PTGS2MEN1KMT2AMAPTABCC4 | |
| SCHEMBL7203048 | 0.83 | ALDH1A1 (0.50) | PTGS2MEN1KMT2AMAPTSIRT1 | |
| SCHEMBL6168377 | 0.83 | MEN1 (0.46) | PTGS2MEN1KMT2AMAPTABCC4 | |
| SCHEMBL6170363 | 0.82 | ALOX15 (0.43) | PTGS2MEN1KMT2AMAPTABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |