Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.46 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.43 |
| ▸ | COMT | P21964 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6181826 | 0.91 | RET (0.48) | ALDH1A1RAB9AKDM4EHSD17B10CYP3A4 | |
| SCHEMBL6169499 | 0.83 | ABL1 (0.40) | ALDH1A1RAB9AKDM4EHSD17B10CYP3A4 | |
| SCHEMBL6170872 | 0.80 | TDP1 (0.46) | ALDH1A1RAB9AKDM4EHSD17B10CYP3A4 | |
| SCHEMBL6170913 | 0.80 | KMO (0.48) | ALDH1A1RAB9AKDM4EHSD17B10CYP3A4 | |
| SCHEMBL6168228 | 0.80 | KDM4E (0.46) | ALDH1A1RAB9AKDM4EHSD17B10CYP3A4 | |
| SCHEMBL6170787 | 0.79 | DYRK1A (0.42) | ALDH1A1RAB9AKDM4EHSD17B10CYP3A4 | |
| SCHEMBL6170009 | 0.79 | EGLN1 (0.42) | — | |
| SCHEMBL6170477 | 0.79 | HASPIN (0.42) | ALDH1A1RAB9AKDM4EHSD17B10CYP3A4 | |
| SCHEMBL7197087 | 0.76 | GRM2 (0.40) | ALDH1A1RAB9AKDM4EHSD17B10CYP3A4 | |
| SCHEMBL6169951 | 0.75 | TSPO (0.46) | ALDH1A1RAB9AKDM4ENPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097138-B1 | PHARMACEUTICAL COMPOSITIONS COMPRISING 2-QUINOLONES | LAFON LABOR (FR) | 2005-12-07 | — | — | EP | disclosed |
| US-6593342-B1 | Activity on the proliferation of clonogenic cells in tumours and comprising an efficient amount of a compound selected among the compounds | LABORATOIRE L. LAFON (FR) | 2003-07-15 | — | — | US | disclosed |
| EP-1097138-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING 2-QUINOLONES | LABORATOIRE L. LAFON (FR) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000003990-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING 2-QUINOLONES | LABORATOIRE L. LAFON (FR) | 2000-01-27 | — | — | WO | disclosed |