Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 18/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 17/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3364389 | 0.82 | ALDH1A1 (0.44) | DPP4SCD | |
| SCHEMBL3366040 | 0.81 | HCRTR1 (0.56) | HCRTR2HCRTR1SCD | |
| SCHEMBL6069077 | 0.73 | ALDH1A1 (0.44) | HCRTR2HCRTR1DPP4SCD | |
| SCHEMBL3370704 | 0.71 | HCRTR1 (0.63) | HCRTR2HCRTR1 | |
| SCHEMBL3364395 | 0.71 | ALDH1A1 (0.49) | — | |
| SCHEMBL3369449 | 0.70 | ALDH1A1 (0.46) | DPP4 | |
| SCHEMBL3368142 | 0.69 | CYP2C19 (0.44) | HCRTR2HCRTR1DPP4 | |
| SCHEMBL3367004 | 0.67 | CYP2C19 (0.41) | HCRTR2HCRTR1 | |
| SCHEMBL3370780 | 0.67 | CYP2C19 (0.41) | HCRTR2HCRTR1 | |
| SCHEMBL3366667 | 0.67 | KDM4E (0.43) | HCRTR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532141-A1 | 2-PYRROLIDIN-2-YL- 1,3,4]-OXADIAZOLE DERIVATIVES AND THE USE OF THE SAME AS ANTIDEPRESSANTS | Grünenthal GmbH (DE) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004024725-A1 | 2-PYRROLIDIN-2-YL-[1,3,4]-OXADIAZOLE DERIVATIVES AND THE USE OF THE SAME AS ANTIDEPRESSANTS | Grünenthal GmbH (DE) | 2004-03-25 | — | — | WO | disclosed |