Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11257898 | 0.93 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL9617476 | 0.91 | ALDH1A1 (0.44) | ALDH1A1LMNAHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL5075813 | 0.88 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL11648171 | 0.87 | TP53 (0.41) | ALDH1A1LMNAHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL4944171 | 0.85 | ALDH1A1 (0.52) | ALDH1A1LMNAHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL19703069 | 0.85 | SMN1; SMN2 (0.38) | ALDH1A1LMNAHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL1919905 | 0.84 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL10253096 | 0.84 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL14946230 | 0.82 | ALDH1A1 (0.44) | ALDH1A1LMNAHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL4148198 | 0.80 | ALDH1A1 (0.42) | ALDH1A1LMNAHSD17B10TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0022440-A1 | Process for preparing Michael addition products and for converting them to ibuprofen, an anti-inflammatory compound | THE UPJOHN COMPANY (US) | 1981-01-21 | — | — | EP | claimed |
| US-4194053-A | Process for preparing esters of α-acetyl-α'-methylsuccinic acid and esters of α-methyl-α'-acetyl-α'-(5-methyl-3-oxohexyl)succinic acid | THE UPJOHN COMPANY (US) | 1980-03-18 | — | — | US | claimed |
| US-6953789-B2 | Thiol compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-10-11 | — | — | US | disclosed |
| US-20040157894-A1 | Thiol compounds, their production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-08-12 | — | — | US | disclosed |
| US-6699881-B2 | MATRIX METALLOPROTEASE INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2004-03-02 | — | — | US | disclosed |
| US-20030078253-A1 | Thiol compounds, their production and use | TAKEDA PHARMACEUTICAL COMPANY, LIMITED (JP) | 2003-04-24 | — | — | US | disclosed |
| US-6420415-B1 | Thiol compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1132379-A1 | NOVEL THIOL DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND UTILIZATION THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2001-09-12 | — | — | EP | disclosed |
| US-4338459-A | FROM 2-HALOPROPIONATE ESTER AND ACETOACETIC ACID ESTER | THE UPJOHN COMPANY (US) | 1982-07-06 | — | — | US | disclosed |
| EP-0022440-A1 | Process for preparing Michael addition products and for converting them to ibuprofen, an anti-inflammatory compound | THE UPJOHN COMPANY (US) | 1981-01-21 | — | — | EP | disclosed |
| US-4194053-A | Process for preparing esters of α-acetyl-α'-methylsuccinic acid and esters of α-methyl-α'-acetyl-α'-(5-methyl-3-oxohexyl)succinic acid | THE UPJOHN COMPANY (US) | 1980-03-18 | — | — | US | disclosed |
| US-4008270-A | Process for preparing 2-(substituted phenyl)propionic acids | THE UPJOHN COMPANY (US) | 1977-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078253-A1 | Thiol compounds, their production and use | TST, QSOX1, SULT1E1 | ALDH1A1 905/4885LMNA 4373/4885HSD17B10 520/4885 |
| US-20040157894-A1 | Thiol compounds, their production and use | TST, SULT1E1, QSOX1 | ALDH1A1 877/4885LMNA 4464/4885HSD17B10 403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.