Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | CBLB | Q13191 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174358 | 0.93 | NPC1 (0.39) | ALDH1A1RAB9ANPC1GAACYP2C9 | |
| SCHEMBL6173783 | 0.93 | LMNA (0.44) | ALDH1A1RAB9ANPC1IGF1RGAA | |
| SCHEMBL6173058 | 0.92 | IGF1R (0.36) | ALDH1A1IGF1RGAACYP2C9CYP3A4 | |
| SCHEMBL6175398 | 0.92 | GRM5 (0.43) | ALDH1A1RAB9ANPC1GAACYP2C9 | |
| SCHEMBL6753615 | 0.91 | GAA (0.46) | ALDH1A1RAB9ANPC1GAACYP2C9 | |
| SCHEMBL6174924 | 0.90 | EPHX2 (0.39) | RAB9ANPC1IGF1RCYP2C9LMNA | |
| SCHEMBL6175127 | 0.89 | CYP2C9 (0.38) | ALDH1A1RAB9ANPC1IGF1RGAA | |
| SCHEMBL6172274 | 0.86 | CYP3A4 (0.40) | ALDH1A1RAB9ANPC1ATMMAPK9 | |
| SCHEMBL6175073 | 0.85 | IGF1R (0.38) | RAB9AIGF1RCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL6175269 | 0.85 | MAPT (0.40) | ALDH1A1IGF1RGAACYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |