Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | CASR | P41180 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171030 | 0.91 | LMNA (0.40) | LMNAPOLBL3MBTL1GPR139TRPV4 | |
| SCHEMBL6174955 | 0.91 | LMNA (0.40) | LMNAPOLBL3MBTL1GPR139TRPV4 | |
| SCHEMBL6171217 | 0.90 | GPR139 (0.43) | LMNAGPR139 | |
| SCHEMBL6175890 | 0.89 | LMNA (0.39) | LMNAPOLBL3MBTL1GPR139TRPV4 | |
| SCHEMBL6172559 | 0.86 | LMNA (0.37) | LMNAMAPK7POLBL3MBTL1GPR139 | |
| SCHEMBL6175238 | 0.84 | IGF1R (0.43) | LMNAPOLBL3MBTL1NPSR1ALDH1A1 | |
| SCHEMBL6173959 | 0.80 | LMNA (0.40) | LMNAPOLBL3MBTL1TRPV4MCHR1 | |
| SCHEMBL6174388 | 0.79 | MAPK7 (0.39) | MAPK7POLBL3MBTL1GPR139TRPV4 | |
| SCHEMBL6173698 | 0.77 | LMNA (0.42) | LMNAPOLBL3MBTL1PDE2AMCHR1 | |
| SCHEMBL6171781 | 0.77 | P2RX3 (0.36) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |