Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CCR9 | P51686 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | LIPE | Q05469 | 4/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172100 | 0.87 | LMNA (0.38) | LMNANPBWR1MCHR1L3MBTL1POLB | |
| SCHEMBL6173186 | 0.86 | LMNA (0.40) | LMNANPBWR1MCHR1L3MBTL1POLB | |
| SCHEMBL6172442 | 0.85 | LMNA (0.40) | LMNANPBWR1MCHR1L3MBTL1POLB | |
| SCHEMBL6170501 | 0.85 | LMNA (0.42) | LMNAL3MBTL1POLBCXCR3KDM4C | |
| SCHEMBL6172197 | 0.85 | LMNA (0.40) | LMNANPBWR1MCHR1L3MBTL1POLB | |
| SCHEMBL6176359 | 0.85 | LMNA (0.39) | LMNANPBWR1MCHR1L3MBTL1POLB | |
| SCHEMBL6177656 | 0.84 | LMNA (0.37) | LMNAL3MBTL1POLBCYP3A4 | |
| SCHEMBL6170777 | 0.84 | LMNA (0.38) | LMNANPBWR1MCHR1L3MBTL1POLB | |
| SCHEMBL6176406 | 0.84 | LMNA (0.39) | LMNAL3MBTL1POLBCXCR3CYP3A4 | |
| SCHEMBL6174750 | 0.84 | LMNA (0.39) | LMNANPBWR1MCHR1L3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |