SCHEMBL6172380

SCHEMBL6172380

CC(=O)Nc1nc[c]cn1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.43
CYP1A2 P05177 2/20 0.42
POLB P06746 2/20 0.41
HTT P42858 2/20 0.39
LMNA P02545 2/20 0.39
ADORA3 P0DMS8 3/20 0.39
ADORA1 P30542 1/20 0.39
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
PTK2 Q05397 1/20 0.37
HSD17B10 Q99714 2/20 0.37
GAA P10253 2/20 0.37
PKM P14618 1/20 0.37
ALOX15 P16050 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
NAPRT Q6XQN6 1/20 0.37
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
KDM4E B2RXH2 2/20 0.36
PRNP P04156 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2491687 0.76 LMNA (0.63) L3MBTL1CYP1A2POLBHTTLMNA
SCHEMBL4927069 0.75 L3MBTL1 (0.38) L3MBTL1CYP1A2POLBHTTADORA3
SCHEMBL9948710 0.74 L3MBTL1 (0.50) L3MBTL1CYP1A2POLBHTTLMNA
SCHEMBL9321428 0.74 CYP1A2 (0.41) L3MBTL1CYP1A2POLBLMNAADORA3
SCHEMBL14069596 0.73 LMNA (0.45) L3MBTL1CYP1A2POLBHTTLMNA
SCHEMBL13304496 0.73 ADORA3 (0.46) L3MBTL1CYP1A2POLBHTTLMNA
SCHEMBL15184467 0.71 L3MBTL1 (0.42) L3MBTL1CYP1A2POLBHTTLMNA
SCHEMBL11470783 0.71 PTK2 (0.58) L3MBTL1CYP1A2POLBHTTLMNA
SCHEMBL1069160 0.71 L3MBTL1 (0.42) L3MBTL1CYP1A2POLBHTTLMNA
SCHEMBL10588098 0.71 L3MBTL1 (0.42) L3MBTL1CYP1A2POLBHTTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140128373-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON INC. 2014-05-08 US claimed
EP-2672967-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR Plexxikon, Inc. (US) 2013-12-18 EP claimed
WO-2012109075-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON INC. (US) 2012-08-16 WO claimed
EP-0794774-B1 4,4-(DISUBSTITUTED)CYCLOHEXAN-1-OLS MONOMERS AND RELATED COMPOUNDS SMITHKLINE BEECHAM CORP (US) 2005-10-12 EP claimed
US-20240199635-A1 TETRAHYDROTHIENO PYRIDINE DERIVATIVES AS DDRS INHIBITORS CHIESI FARMACEUTICI S.P.A. (IT) 2024-06-20 US disclosed
US-20240190847-A1 INDOLINE DERIVATIVES AS DDR1 AND DDR2 INHIBITORS CHIESI FARMACEUTICI S.P.A. (IT) 2024-06-13 US disclosed
EP-4313292-A1 INDOLINE DERIVATIVES AS DDR1 AND DDR2 INHIBITORS Chiesi Farmaceutici S.p.A. (IT) 2024-02-07 EP disclosed
EP-4313994-A1 TETRAHYDROTHIENO PYRIDINE DERIVATIVES AS DDRS INHIBITORS Chiesi Farmaceutici S.p.A. (IT) 2024-02-07 EP disclosed
CN-117120434-A Indoline derivatives as DDR1 and DDR2 inhibitors 奇斯药制品公司 2023-11-24 CN disclosed
US-20230277534-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON INC. 2023-09-07 US disclosed
US-11337976-B2 Compounds and methods for kinase modulation, and indications therefor PLEXXIKON INC. (US) 2022-05-24 US disclosed
EP-2672967-B1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON INC (US) 2018-10-17 EP disclosed
US-9624213-B2 Compounds and methods for kinase modulation, and indications therefor PLEXXIKON INC. (US) 2017-04-18 US disclosed
US-20140128373-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON INC. 2014-05-08 US disclosed
CN-103517710-A Compounds and methods for kinase modulation, and indications therefor PLEXXIKON INC 2014-01-15 CN disclosed
EP-0794774-B1 4,4-(DISUBSTITUTED)CYCLOHEXAN-1-OLS MONOMERS AND RELATED COMPOUNDS SMITHKLINE BEECHAM CORP (US) 2005-10-12 EP disclosed
US-5616579-A ADMINISTERING TO MAMMALS TO PREVENT GASTRIC ULCER SANKYO COMPANY, LIMITED (JP) 1997-04-01 US disclosed
EP-0562833-B1 Anti-ulcer pyridyloxy derivatives, their preparation and uses SANKYO CO (JP) 1996-05-08 EP disclosed
CN-1081437-A Antiulcer pyridine oxygen derivative, their preparation method and purposes SANKYO CO (JP) 1994-02-02 CN disclosed
EP-0562833-A1 Anti-ulcer pyridyloxy derivatives, their preparation and uses SANKYO COMPANY LIMITED (JP) 1993-09-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240190847-A1 INDOLINE DERIVATIVES AS DDR1 AND DDR2 INHIBITORS DDR1, DDR2, DDRGK1 L3MBTL1 3101/4885CYP1A2 3511/4885POLB 2296/4885
US-11337976-B2 Compounds and methods for kinase modulation, and indications therefor MAP3K20, PRKACA, MAP3K13 L3MBTL1 861/4885CYP1A2 4746/4885POLB 1542/4885
US-20230277534-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR MAP3K20, PRKACA, MAP3K13 L3MBTL1 861/4885CYP1A2 4746/4885POLB 1542/4885
US-20140128373-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR MAP3K20, PRKACA, MAP3K13 L3MBTL1 861/4885CYP1A2 4746/4885POLB 1542/4885
US-20240199635-A1 TETRAHYDROTHIENO PYRIDINE DERIVATIVES AS DDRS INHIBITORS DDR1, DDR2, DDRGK1 L3MBTL1 3180/4885CYP1A2 4827/4885POLB 1902/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.