Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 4/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.34 |
| ▸ | CCR9 | P51686 | 2/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173841 | 0.90 | LIPE (0.41) | LMNALIPECXCR3CCR9KDM5A | |
| SCHEMBL6177185 | 0.89 | LMNA (0.41) | LMNALIPECCR9 | |
| SCHEMBL6174151 | 0.89 | NAMPT (0.35) | LMNAELANENAMPTLARS1HTT | |
| SCHEMBL6172043 | 0.88 | IGF1R (0.37) | LMNAKDM4CELANENAMPT | |
| SCHEMBL6175499 | 0.87 | LMNA (0.37) | LMNALIPECXCR3CCR9 | |
| SCHEMBL6207151 | 0.87 | CCR9 (0.44) | LMNALIPECCR9 | |
| SCHEMBL6173186 | 0.82 | LMNA (0.40) | LMNALIPECXCR3CCR9KDM4C | |
| SCHEMBL6175038 | 0.82 | LMNA (0.38) | LMNALIPEKDRKCNH2SCN5A | |
| SCHEMBL6173298 | 0.81 | LMNA (0.39) | LMNALIPEFLT1KDRCXCR3 | |
| SCHEMBL6172197 | 0.81 | LMNA (0.40) | LMNALIPECXCR3CCR9KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |