Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 4/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170859 | 0.83 | ALDH1A1 (0.41) | ALDH1A1TP53SMN1; SMN2HPGDMAPT | |
| SCHEMBL7470525 | 0.74 | ADORA2A (0.39) | TP53MAPTHSD17B10ADORA2AADORA2B | |
| SCHEMBL6173264 | 0.73 | ALDH1A1 (0.49) | ALDH1A1TP53SMN1; SMN2HPGDMAPT | |
| SCHEMBL6171990 | 0.71 | ALDH1A1 (0.40) | ALDH1A1TP53SMN1; SMN2HPGDMAPT | |
| SCHEMBL6173367 | 0.71 | MAPT (0.48) | ALDH1A1TP53SMN1; SMN2HPGDMAPT | |
| SCHEMBL6170768 | 0.71 | TP53 (0.54) | ALDH1A1TP53SMN1; SMN2HPGDMAPT | |
| SCHEMBL6170577 | 0.69 | TP53 (0.45) | ALDH1A1TP53SMN1; SMN2HPGDMAPT | |
| SCHEMBL8997219 | 0.64 | PTGS1 (0.58) | ALDH1A1TP53SMN1; SMN2HPGDMAPT | |
| SCHEMBL7398150 | 0.64 | SMN1; SMN2 (0.40) | ALDH1A1TP53SMN1; SMN2HPGDTSHR | |
| SCHEMBL6612626 | 0.64 | ADORA2A (0.38) | ALDH1A1TP53SMN1; SMN2HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263757-A1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | Darwin Discovery Limited (GB) | 2002-12-11 | — | — | EP | claimed |
| WO-2001058897-A1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-08-16 | — | — | WO | claimed |
| EP-1263757-B1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2005-07-27 | — | — | EP | disclosed |
| EP-1263757-A1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | Darwin Discovery Limited (GB) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001058897-A1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-08-16 | — | — | WO | disclosed |