Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.33 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175577 | 0.85 | EPHX2 (0.40) | LMNAABL1ALDH1A1MAPK7 | |
| SCHEMBL6173698 | 0.84 | LMNA (0.42) | LMNACYP3A4POLBL3MBTL1 | |
| SCHEMBL6173186 | 0.81 | LMNA (0.40) | LMNAPOLBL3MBTL1GPR139 | |
| SCHEMBL6173490 | 0.81 | ABL1 (0.44) | LMNATRPV4MAP4K1POLBL3MBTL1 | |
| SCHEMBL6172197 | 0.80 | LMNA (0.40) | LMNAPOLBL3MBTL1 | |
| SCHEMBL6172442 | 0.80 | LMNA (0.40) | LMNACYP3A4POLBL3MBTL1 | |
| SCHEMBL6170501 | 0.80 | LMNA (0.42) | LMNAPOLBL3MBTL1 | |
| SCHEMBL6171386 | 0.80 | LMNA (0.38) | LMNAPOLBL3MBTL1 | |
| SCHEMBL6176359 | 0.79 | LMNA (0.39) | LMNAPOLBL3MBTL1 | |
| SCHEMBL6174909 | 0.79 | TRPV4 (0.37) | TRPV4MAP4K1CYP3A4POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |