Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6022725 | 0.85 | MAOA (0.38) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL28460903 | 0.84 | CYP2D6 (0.48) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL8935647 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPK1GAANPC1RAB9A | |
| SCHEMBL8935651 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPK1GAANPC1RAB9A | |
| SCHEMBL4744285 | 0.77 | SMN1; SMN2 (0.45) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL3110670 | 0.77 | SMN1; SMN2 (0.45) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL9522361 | 0.77 | GAA (0.41) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL15677583 | 0.77 | HTR1A (0.66) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL29530994 | 0.76 | GAA (0.50) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL1871847 | 0.76 | GAA (0.50) | HTR1AADRA2AADRA2BMAOAHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513807-A1 | PHARMACEUTICAL COMBINATION | AstraZeneca AB (SE) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003101956-A1 | PHARMACEUTICAL COMBINATION | ASTRAZENECA AB (SE) | 2003-12-11 | — | — | WO | disclosed |