Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | LIPE | Q05469 | 3/20 | 0.32 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172100 | 0.92 | LMNA (0.38) | LMNAPOLBL3MBTL1CACNA1BCXCR3 | |
| SCHEMBL6170777 | 0.85 | LMNA (0.38) | LMNAPOLBL3MBTL1CXCR3NPBWR1 | |
| SCHEMBL6172336 | 0.85 | CACNA1B (0.34) | LMNACACNA1BSLC22A12 | |
| SCHEMBL6173698 | 0.84 | LMNA (0.42) | LMNAPOLBL3MBTL1CXCR3LIPE | |
| SCHEMBL6173186 | 0.82 | LMNA (0.40) | LMNAPOLBL3MBTL1CXCR3LIPE | |
| SCHEMBL6277100 | 0.82 | GSK3A (0.38) | LIPEMAPT | |
| SCHEMBL6170501 | 0.81 | LMNA (0.42) | LMNAPOLBL3MBTL1CXCR3LIPE | |
| SCHEMBL6172442 | 0.81 | LMNA (0.40) | LMNAPOLBL3MBTL1CXCR3LIPE | |
| SCHEMBL6172197 | 0.81 | LMNA (0.40) | LMNAPOLBL3MBTL1CXCR3LIPE | |
| SCHEMBL6173062 | 0.81 | LMNA (0.37) | LMNACACNA1BSLC22A12MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |