Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 8/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172551 | 0.91 | ALDH1A1 (0.39) | LMNAALDH1A1SMN1; SMN2TSHRHTT | |
| SCHEMBL13720522 | 0.84 | IDO1 (0.43) | LMNASMN1; SMN2KMT2AL3MBTL1MAPT | |
| SCHEMBL13720294 | 0.84 | IDO1 (0.43) | LMNASMN1; SMN2KMT2AL3MBTL1MAPT | |
| SCHEMBL6173014 | 0.79 | CHRNB2 (0.35) | ALDH1A1TSHRCYP3A4 | |
| SCHEMBL6171093 | 0.79 | CHRNB2 (0.35) | ALDH1A1TSHRCYP3A4 | |
| SCHEMBL13720464 | 0.75 | SYK (0.45) | ALDH1A1MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL13720143 | 0.75 | SYK (0.45) | ALDH1A1MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL13720411 | 0.75 | SYK (0.45) | ALDH1A1MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL13720497 | 0.71 | OPRK1 (0.46) | LMNATSHRKDM4E | |
| SCHEMBL4019403 | 0.71 | OPRK1 (0.46) | LMNATSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569934-A2 | CYCLOPROPYL COMPOUNDS AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004055010-A2 | CYCLOPROPYL COMPOUNDS AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-07-01 | — | — | WO | disclosed |