Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.34 |
| ▸ | MLYCD | O95822 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
| ▸ | GABRE | P78334 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172914 | 0.88 | IGF1R (0.38) | IGF1RARTRPV3KMT2AHRH4 | |
| SCHEMBL6174541 | 0.87 | SLC5A1 (0.40) | MAPTMLYCD | |
| SCHEMBL6172497 | 0.87 | IGF1R (0.37) | IGF1RMAPTARTRPV3KMT2A | |
| SCHEMBL6175269 | 0.86 | MAPT (0.40) | IGF1RMAPTARTRPV3KMT2A | |
| SCHEMBL6174371 | 0.86 | IGF1R (0.44) | IGF1RMAPT | |
| SCHEMBL6175494 | 0.84 | IGF1R (0.35) | IGF1RARTRPV3KMT2AHRH4 | |
| SCHEMBL6203204 | 0.83 | IGF1R (0.40) | IGF1RMAPTARTRPV3KMT2A | |
| SCHEMBL6175019 | 0.83 | DPP4 (0.37) | IGF1RCHRNA7ARTRPV3KMT2A | |
| SCHEMBL6175022 | 0.83 | IGF1R (0.40) | IGF1RARTRPV3KMT2AHRH4 | |
| SCHEMBL6175941 | 0.82 | PTGS2 (0.39) | IGF1RAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |