Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175019 | 0.90 | DPP4 (0.37) | IGF1RTACR1SCN9ASCN7AKCNH2 | |
| SCHEMBL6175941 | 0.89 | PTGS2 (0.39) | IGF1RTACR1SCN9ASCN7AKCNH2 | |
| SCHEMBL6173425 | 0.88 | LMNA (0.38) | IGF1RL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL6172914 | 0.85 | IGF1R (0.38) | IGF1RMEN1KMT2AARTRPV3 | |
| SCHEMBL6173852 | 0.84 | IGF1R (0.37) | IGF1RKMT2AARTRPV3HRH4 | |
| SCHEMBL6203204 | 0.81 | IGF1R (0.40) | IGF1RMEN1KMT2AARTRPV3 | |
| SCHEMBL6175022 | 0.80 | IGF1R (0.40) | IGF1RMEN1KMT2AARTRPV3 | |
| SCHEMBL6172497 | 0.79 | IGF1R (0.37) | IGF1RALDH1A1KMT2AARTRPV3 | |
| SCHEMBL6201343 | 0.79 | PTGS2 (0.40) | IGF1RMEN1KMT2AARTRPV3 | |
| SCHEMBL6177630 | 0.79 | IGF1R (0.39) | IGF1RMEN1KMT2AARTRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |