Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.35 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173495 | 0.89 | KCNK2 (0.41) | KCNK2KCNK10LMNAMAPTGAA | |
| SCHEMBL6177285 | 0.88 | TDP1 (0.42) | DCTPP1ALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6173749 | 0.88 | KCNK2 (0.42) | KCNK2KCNK10NPC1LMNAMAPT | |
| SCHEMBL6173116 | 0.86 | KCNK2 (0.38) | ALDH1A1KCNK2KCNK10CYP1A2CYP3A4 | |
| SCHEMBL6175146 | 0.84 | LMNA (0.39) | ALDH1A1KCNK2KCNK10CYP1A2NPC1 | |
| SCHEMBL6174745 | 0.83 | IGF1R (0.34) | NPC1RAB9ALMNASMN1; SMN2IGF1R | |
| SCHEMBL6174079 | 0.83 | KCNK2 (0.45) | ALDH1A1KCNK2KCNK10CYP3A4CYP2C19 | |
| SCHEMBL6174730 | 0.83 | RXFP1 (0.39) | ALDH1A1LMNAMAPTTSHRL3MBTL1 | |
| SCHEMBL6171775 | 0.82 | IGF1R (0.38) | ALDH1A1CYP3A4MEN1KMT2AMAPT | |
| SCHEMBL6173954 | 0.82 | IGF1R (0.36) | LMNAIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |