Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175146 | 0.89 | LMNA (0.39) | IGF1RLMNANTRK1P2RX3NPC1 | |
| SCHEMBL6171505 | 0.87 | IGF1R (0.34) | IGF1RLMNANTRK1NPC1RAB9A | |
| SCHEMBL6174779 | 0.87 | LMNA (0.36) | LMNANPC1RAB9A | |
| SCHEMBL6174685 | 0.86 | RXFP1 (0.36) | IGF1RLMNA | |
| SCHEMBL6173495 | 0.86 | KCNK2 (0.41) | LMNAPDE2A | |
| SCHEMBL6172178 | 0.85 | IGF1R (0.33) | IGF1RNTRK1 | |
| SCHEMBL6173990 | 0.85 | IGF1R (0.39) | IGF1RLMNAPDE2A | |
| SCHEMBL6174079 | 0.85 | KCNK2 (0.45) | LMNANPC1RAB9ASMN1; SMN2PDE2A | |
| SCHEMBL6174730 | 0.85 | RXFP1 (0.39) | IGF1RLMNA | |
| SCHEMBL6173749 | 0.85 | KCNK2 (0.42) | IGF1RLMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |