Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK2 | O95069 | 10/20 | 0.41 |
| ▸ | KCNK10 | P57789 | 7/20 | 0.41 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173749 | 0.92 | KCNK2 (0.42) | KCNK2KCNK10LMNATRPV1MAPT | |
| SCHEMBL6173116 | 0.91 | KCNK2 (0.38) | KCNK2KCNK10TEKBRAFMAPT | |
| SCHEMBL6174079 | 0.91 | KCNK2 (0.45) | KCNK2KCNK10LMNAPDE2AMAPT | |
| SCHEMBL6174000 | 0.89 | DCTPP1 (0.35) | KCNK2KCNK10LMNAMAPTGAA | |
| SCHEMBL6175146 | 0.88 | LMNA (0.39) | KCNK2KCNK10LMNAPDE2A | |
| SCHEMBL6171775 | 0.87 | IGF1R (0.38) | TRPV1MAPT | |
| SCHEMBL6174745 | 0.86 | IGF1R (0.34) | LMNAPDE2A | |
| SCHEMBL6173990 | 0.84 | IGF1R (0.39) | LMNAPDE2A | |
| SCHEMBL6174730 | 0.84 | RXFP1 (0.39) | LMNAMAPTGSK3BGAA | |
| SCHEMBL6176639 | 0.84 | OXTR (0.36) | LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |