Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK2 | O95069 | 4/20 | 0.45 |
| ▸ | KCNK10 | P57789 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | ICOSLG | O75144 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173749 | 0.91 | KCNK2 (0.42) | KCNK2KCNK10GAANPC1LMNA | |
| SCHEMBL6173495 | 0.91 | KCNK2 (0.41) | KCNK2KCNK10GAALMNAPDE2A | |
| SCHEMBL6174987 | 0.90 | GAA (0.41) | GAACYP3A4CYP2C9CYP2C19RAB9A | |
| SCHEMBL6174745 | 0.85 | IGF1R (0.34) | RAB9ANPC1LMNASMN1; SMN2PDE2A | |
| SCHEMBL6173116 | 0.85 | KCNK2 (0.38) | KCNK2KCNK10CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6175146 | 0.84 | LMNA (0.39) | KCNK2KCNK10RAB9ANPC1LMNA | |
| SCHEMBL6277100 | 0.83 | GSK3A (0.38) | RAB9ANPC1MAPT | |
| SCHEMBL6174000 | 0.83 | DCTPP1 (0.35) | KCNK2KCNK10GAACYP3A4CYP2C19 | |
| SCHEMBL6173062 | 0.83 | LMNA (0.37) | GAACYP3A4CYP2C9CYP2C19LMNA | |
| SCHEMBL6171505 | 0.82 | IGF1R (0.34) | CYP2C19RAB9ANPC1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |