Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A1 | P13866 | 5/20 | 0.36 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CBLB | Q13191 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172737 | 0.93 | MAPK1 (0.37) | SLC5A1PDE2AL3MBTL1MAPK1LMNA | |
| SCHEMBL6175310 | 0.91 | MCHR1 (0.35) | SLC5A1PDE2AMAPK1LMNACBLB | |
| SCHEMBL6175093 | 0.89 | IGF1R (0.44) | PDE2ANPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL6172454 | 0.89 | GAA (0.36) | NPC1HPGDRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL6173626 | 0.88 | SLC5A1 (0.37) | SLC5A1PDE2AMAPK1LMNACBLB | |
| SCHEMBL6171770 | 0.86 | LMNA (0.43) | SLC5A1PDE2AMAPK1LMNACBLB | |
| SCHEMBL6172084 | 0.83 | LMNA (0.40) | SLC5A1PDE2AL3MBTL1MAPK1LMNA | |
| SCHEMBL6174274 | 0.83 | GCGR (0.42) | SLC5A1LIPEPDE2ANPC1RAB9A | |
| SCHEMBL6177704 | 0.83 | KDR (0.42) | SLC5A1 | |
| SCHEMBL6173730 | 0.83 | IDH1 (0.42) | NPC1RAB9AMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |