Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.35 |
| ▸ | SLC5A1 | P13866 | 3/20 | 0.34 |
| ▸ | PDE2A | O00408 | 5/20 | 0.33 |
| ▸ | CBLB | Q13191 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174018 | 0.91 | SLC5A1 (0.36) | SLC5A1PDE2ACBLBMAPK1LMNA | |
| SCHEMBL6172737 | 0.90 | MAPK1 (0.37) | SLC5A1PDE2ACBLBMAPK1LMNA | |
| SCHEMBL6174445 | 0.89 | IGF1R (0.43) | MCHR1PDE2A | |
| SCHEMBL6174416 | 0.88 | IGF1R (0.33) | CBLB | |
| SCHEMBL6173626 | 0.85 | SLC5A1 (0.37) | SLC5A1PDE2ACBLBMAPK1LMNA | |
| SCHEMBL6171770 | 0.83 | LMNA (0.43) | SLC5A1PDE2ACBLBMAPK1LMNA | |
| SCHEMBL6174276 | 0.82 | MAPK1 (0.34) | MCHR1SLC5A1PDE2ACBLBKDR | |
| SCHEMBL6172084 | 0.81 | LMNA (0.40) | MCHR1SLC5A1PDE2AMAPK1LMNA | |
| SCHEMBL6175093 | 0.81 | IGF1R (0.44) | PDE2A | |
| SCHEMBL6174274 | 0.80 | GCGR (0.42) | SLC5A1PDE2ACBLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |