Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 15/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 3/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177171 | 0.92 | IGF1R (0.46) | IGF1RL3MBTL1PDE2A | |
| SCHEMBL6174445 | 0.90 | IGF1R (0.43) | IGF1RPDE2A | |
| SCHEMBL6174018 | 0.89 | SLC5A1 (0.36) | IGF1RNPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL6172454 | 0.87 | GAA (0.36) | IGF1RNPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL6177806 | 0.85 | IGF1R (0.43) | IGF1RPDE2A | |
| SCHEMBL6173765 | 0.82 | KCNK2 (0.44) | IGF1RNPC1RAB9APDE2A | |
| SCHEMBL6172737 | 0.82 | MAPK1 (0.37) | L3MBTL1PDE2A | |
| SCHEMBL6174760 | 0.82 | IGF1R (0.41) | IGF1RNPC1RAB9APDE2A | |
| SCHEMBL6171505 | 0.82 | IGF1R (0.34) | IGF1RNPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL6176013 | 0.81 | IGF1R (0.41) | IGF1RNPC1RAB9APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |