Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28192442 | 0.80 | CYP1A2 (0.39) | MAPTLMNAGAAMEN1KMT2A | |
| SCHEMBL1558545 | 0.80 | S1PR4 (0.39) | MAPTLMNAGAAMEN1KMT2A | |
| SCHEMBL18474451 | 0.80 | ALDH1A1 (0.39) | MAPTLMNAGAAMEN1KMT2A | |
| SCHEMBL4252080 | 0.80 | MAPT (0.38) | MAPTLMNAGAAMEN1KMT2A | |
| SCHEMBL7682478 | 0.80 | MAPT (0.40) | MAPTLMNAGAAMEN1KMT2A | |
| SCHEMBL2124836 | 0.80 | MAPT (0.38) | MAPTLMNAGAAMEN1KMT2A | |
| SCHEMBL29004856 | 0.76 | S1PR4 (0.35) | MAPTLMNAGAAMEN1KMT2A | |
| SCHEMBL29947327 | 0.76 | KMT2A (0.38) | MAPTLMNAMEN1KMT2AS1PR4 | |
| SCHEMBL21383944 | 0.76 | KMT2A (0.38) | MAPTLMNAMEN1KMT2AS1PR4 | |
| SCHEMBL28992901 | 0.76 | ALDH1A1 (0.40) | MAPTLMNAGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107635993-B | Substituted tricyclic heterocyclic compounds | 百时美施贵宝公司 | 2020-05-22 | — | — | CN | disclosed |
| EP-3271360-B1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2020-04-22 | — | — | EP | disclosed |
| US-10189840-B2 | Substituted tricyclic heterocyclic compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-01-29 | — | — | US | disclosed |
| US-20180111936-A1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2018-04-26 | — | — | US | disclosed |
| EP-3271360-A1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS | Bristol-Myers Squibb Company (US) | 2018-01-24 | — | — | EP | disclosed |
| WO-2016149436-A1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-09-22 | — | — | WO | disclosed |
| EP-1581529-A1 | BENZOXAZINES AND DERIVATIVES THEREOF AS INHIBITORS OF PI3KS | WARNER-LAMBERT COMPANY (US) | 2005-10-05 | — | — | EP | disclosed |
| US-20040138199-A1 | Benzoxazines and derivatives thereof as therapeutic agents | GOGLIOTTI ROCCO DEAN (US) | 2004-07-15 | — | — | US | disclosed |
| WO-2004056820-A1 | BENZOXAZINES AND DERIVATIVES THEREOF AS INHIBITORS OF PI3KS | WARNER-LAMBERT COMPANY LLC (US) | 2004-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180111936-A1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS | CXCR3, CNKSR1, CCR3 | MAPT 4701/4885LMNA 3965/4885GAA 3195/4885 |
| US-20040138199-A1 | Benzoxazines and derivatives thereof as therapeutic agents | XDH, TBXA2R, TBXAS1 | MAPT 4677/4885LMNA 474/4885GAA 1066/4885 |
| US-10189840-B2 | Substituted tricyclic heterocyclic compounds | CXCR3, CNKSR1, CCR3 | MAPT 4701/4885LMNA 3965/4885GAA 3195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.