Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBLB | Q13191 | 8/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | TSPO | P30536 | 1/20 | 0.35 |
| ▸ | GPR183 | P32249 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172184 | 0.88 | NPC1 (0.39) | CBLBALDH1A1IGF1RSTIM1ORAI1 | |
| SCHEMBL6175133 | 0.87 | GRM5 (0.43) | CBLBALDH1A1TP53NPC1RAB9A | |
| SCHEMBL6177007 | 0.87 | TDP1 (0.42) | CBLBKDM4E | |
| SCHEMBL6175934 | 0.87 | IGF1R (0.41) | CBLBALDH1A1IGF1RTP53NPC1 | |
| SCHEMBL6174110 | 0.85 | NPC1 (0.39) | CBLBALDH1A1IGF1RNPC1RAB9A | |
| SCHEMBL6173893 | 0.84 | LMNA (0.39) | CBLBALDH1A1IGF1RHTR2ATSPO | |
| SCHEMBL6176337 | 0.83 | NPC1 (0.39) | CBLBALDH1A1KDM4ETP53NPC1 | |
| SCHEMBL6174217 | 0.83 | IGF1R (0.38) | CBLBALDH1A1KDM4EIGF1RHTR2A | |
| SCHEMBL6174834 | 0.83 | GRM1 (0.39) | CBLBIGF1RHTR2ATSPOGPR183 | |
| SCHEMBL6176514 | 0.83 | NAMPT (0.41) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |