Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CBLB | Q13191 | 6/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172184 | 0.92 | NPC1 (0.39) | CBLBNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL6174110 | 0.88 | NPC1 (0.39) | MAPK14CBLBNPC1RAB9AALDH1A1 | |
| SCHEMBL6174034 | 0.87 | CBLB (0.36) | POLBCBLBTP53NPC1RAB9A | |
| SCHEMBL6175302 | 0.87 | GRM5 (0.45) | GRM5MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6176337 | 0.86 | NPC1 (0.39) | MAPK13MAPK12MAPK11MAPK14CBLB | |
| SCHEMBL6174217 | 0.84 | IGF1R (0.38) | CBLBNPC1RAB9AALDH1A1 | |
| SCHEMBL6177664 | 0.84 | IGF1R (0.37) | — | |
| SCHEMBL6172433 | 0.83 | GAA (0.38) | GRM5POLBTP53MAPTBRAF | |
| SCHEMBL6175398 | 0.82 | GRM5 (0.43) | GRM5POLBMAPK13MAPK12MAPK11 | |
| SCHEMBL6173893 | 0.82 | LMNA (0.39) | CBLBTP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |