Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178460 | 0.88 | LIPE (0.38) | METAP2ELANEALDH1A1 | |
| SCHEMBL6172451 | 0.86 | KMT2A (0.36) | NAMPTIGF1RALDH1A1TP53KMT2A | |
| SCHEMBL6172506 | 0.86 | NAMPT (0.40) | NAMPTIGF1RALDH1A1LMNAKDM4E | |
| SCHEMBL6171051 | 0.86 | NAMPT (0.48) | NAMPTELANE | |
| SCHEMBL6172704 | 0.85 | KMT2A (0.35) | NAMPTIGF1RALDH1A1TP53KMT2A | |
| SCHEMBL6172500 | 0.84 | IGF1R (0.39) | NAMPTIGF1RALDH1A1LMNAKDM4E | |
| SCHEMBL6172022 | 0.84 | KMT2A (0.36) | NAMPTIGF1RALDH1A1LMNATP53 | |
| SCHEMBL6173386 | 0.83 | ALDH1A1 (0.41) | NAMPTIGF1RALDH1A1LMNAKMT2A | |
| SCHEMBL6173613 | 0.83 | KIF11 (0.37) | NAMPTIGF1RALDH1A1LMNATP53 | |
| SCHEMBL6175242 | 0.82 | IGF1R (0.38) | NAMPTIGF1RALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |