Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 4/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | CCR9 | P51686 | 2/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174547 | 0.88 | METAP2 (0.37) | METAP2ALDH1A1ELANE | |
| SCHEMBL6169571 | 0.86 | CYP3A4 (0.35) | LIPECXCR3ALDH1A1KDM4CCCR9 | |
| SCHEMBL6174307 | 0.86 | CYP2C9 (0.38) | LIPEALDH1A1CCR9FLT1KDR | |
| SCHEMBL6173573 | 0.84 | CACNA1H (0.41) | CXCR3ALDH1A1KDM5AKDM4CKDM5B | |
| SCHEMBL6278206 | 0.84 | TRPV1 (0.49) | CXCR3ALDH1A1KDM5AKDM4CKDM5B | |
| SCHEMBL6173283 | 0.82 | CYP3A4 (0.38) | LIPEALDH1A1KDM4CCCR9FLT1 | |
| SCHEMBL6173841 | 0.82 | LIPE (0.41) | LIPEMETAP2CXCR3ALDH1A1KDM5A | |
| SCHEMBL6173837 | 0.82 | LIPE (0.38) | LIPEMETAP2ALDH1A1KDM5AKDM4C | |
| SCHEMBL6174515 | 0.82 | ALDH1A1 (0.45) | ALDH1A1KDM4CCYP3A4TRPV1GAA | |
| SCHEMBL6172844 | 0.81 | CYP3A4 (0.40) | CXCR3ALDH1A1KDM5AKDM4CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |