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SCHEMBL6175455

SCHEMBL6175455

CC(c1ccncc1NS(=O)(=O)Nc1ccccc1)C1NC(=O)N(c2ccc(SC(F)(F)F)cc2)C1=O

nearest known ligand 0.35

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.35
▸ IGF1R P08069 5/20 0.34
▸ PTGS1 P23219 4/20 0.33
▸ PTGS2 P35354 4/20 0.33
▸ NTRK1 P04629 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6172459 0.90 IGF1R (0.34) LMNAIGF1R
SCHEMBL6176639 0.89 OXTR (0.36) LMNAIGF1RPTGS1PTGS2
SCHEMBL6172043 0.89 IGF1R (0.37) LMNAIGF1R
SCHEMBL6172477 0.88 IGF1R (0.35) LMNAIGF1R
SCHEMBL6177185 0.87 LMNA (0.41) LMNAPTGS1PTGS2
SCHEMBL6173354 0.86 IGF1R (0.34) LMNAIGF1R
SCHEMBL6173990 0.84 IGF1R (0.39) LMNAIGF1R
SCHEMBL6173495 0.83 KCNK2 (0.41) LMNA
SCHEMBL6172545 0.82 CYP11B2 (0.33) IGF1R
SCHEMBL6175146 0.81 LMNA (0.39) LMNAIGF1RNTRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 — — EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 — — WO disclosed