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SCHEMBL6174685

SCHEMBL6174685

CC(C)OC(=O)Nc1cnccc1C(C)C1NC(=O)N(c2ccc(S(=O)(=O)C(F)(F)F)cc2)C1=O

nearest known ligand 0.36

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ RXFP1 Q9HBX9 2/20 0.36
▸ EPHX2 P34913 1/20 0.32
▸ NAMPT P43490 1/20 0.32
▸ LMNA P02545 1/20 0.32
▸ IGF1R P08069 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6175990 0.89 KIF11 (0.37) RXFP1EPHX2NAMPTLMNAIGF1R
SCHEMBL6175558 0.88 RXFP1 (0.35) RXFP1NAMPTLMNA
SCHEMBL6174779 0.87 LMNA (0.36) LMNA
SCHEMBL6174745 0.86 IGF1R (0.34) LMNAIGF1R
SCHEMBL6176021 0.85 IGF1R (0.34) RXFP1LMNAIGF1R
SCHEMBL6174116 0.84 IGF1R (0.33) LMNAIGF1R
SCHEMBL6174557 0.83 IGF1R (0.33) LMNAIGF1R
SCHEMBL6171910 0.83 NAMPT (0.47) NAMPT
SCHEMBL6176687 0.82 IGF1R (0.33) LMNAIGF1R
SCHEMBL6175175 0.82 IGF1R (0.36) EPHX2LMNAIGF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 — — EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 — — WO disclosed