Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | ITGAL | P20701 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 3/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | MMP3 | P08254 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171101 | 0.93 | TRPA1 (0.43) | MAT2AALDH1A1SCN10AITGALMMP2 | |
| SCHEMBL6174845 | 0.92 | NTRK1 (0.38) | MAT2ASCN10AITGALMMP2MMP1 | |
| SCHEMBL6174199 | 0.89 | IGF1R (0.51) | CYP3A4GAACYP2C9CYP2C19IGF1R | |
| SCHEMBL6173222 | 0.88 | MAPT (0.41) | CYP3A4GAACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6174785 | 0.86 | ITGAL (0.41) | ITGALARMAPT | |
| SCHEMBL6173435 | 0.84 | IGF1R (0.45) | CYP3A4GAACYP2C9CYP2C19IGF1R | |
| SCHEMBL6176754 | 0.84 | ITGAL (0.44) | CYP3A4GAACYP2C9CYP2C19IGF1R | |
| SCHEMBL6175657 | 0.84 | IGF1R (0.45) | CYP3A4GAACYP2C9CYP2C19IGF1R | |
| SCHEMBL6174653 | 0.83 | ITGAL (0.39) | IGF1RITGALARPOLBL3MBTL1 | |
| SCHEMBL6172079 | 0.82 | IGF1R (0.47) | CYP3A4GAACYP2C9CYP2C19IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |