Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 5/20 | 0.36 |
| ▸ | AR | P10275 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 4/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.34 |
| ▸ | CCR6 | P51684 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174845 | 0.90 | NTRK1 (0.38) | ITGALNTRK1AR | |
| SCHEMBL6174753 | 0.86 | MAT2A (0.43) | ITGALARMAPT | |
| SCHEMBL6171101 | 0.86 | TRPA1 (0.43) | ITGALARMAPK1SCN9A | |
| SCHEMBL6177662 | 0.86 | IGF1R (0.40) | ITGALARHTTMAPT | |
| SCHEMBL6174653 | 0.85 | ITGAL (0.39) | ITGALNTRK1ARKCNH2SCN9A | |
| SCHEMBL6175298 | 0.83 | GRM5 (0.45) | NTRK1ABL1 | |
| SCHEMBL2938922 | 0.81 | IGF1R (0.54) | NTRK1 | |
| SCHEMBL6175657 | 0.81 | IGF1R (0.45) | ITGALNTRK1ARGRIN2BKCNH2 | |
| SCHEMBL6176754 | 0.81 | ITGAL (0.44) | ITGALNTRK1ARSCN9A | |
| SCHEMBL6173435 | 0.81 | IGF1R (0.45) | ITGALNTRK1ABL1ARSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |