Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 6/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 2/20 | 0.37 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173730 | 0.89 | IDH1 (0.42) | MAPK1EPHX2LMNA | |
| SCHEMBL6173973 | 0.88 | IGF1R (0.46) | MAPK1 | |
| SCHEMBL6176514 | 0.87 | NAMPT (0.41) | MAPK1NAMPT | |
| SCHEMBL6171770 | 0.86 | LMNA (0.43) | MAPK1LMNASLC5A1 | |
| SCHEMBL6175038 | 0.85 | LMNA (0.38) | MAPK1LMNAKCNH2SCN5ASCN9A | |
| SCHEMBL6172737 | 0.83 | MAPK1 (0.37) | MAPK1LMNASLC5A1 | |
| SCHEMBL6173626 | 0.83 | SLC5A1 (0.37) | MAPK1LMNASLC5A1 | |
| SCHEMBL6172794 | 0.83 | MAPK1 (0.42) | MAPK1EPHX2PTGS2GSK3BKCNH2 | |
| SCHEMBL6177007 | 0.82 | TDP1 (0.42) | LMNAGSK3BSLC5A1 | |
| SCHEMBL6177220 | 0.82 | LMNA (0.40) | LMNATRPV1SLC5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |