Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LIPE | Q05469 | 2/20 | 0.40 |
| ▸ | CBLB | Q13191 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SLC5A1 | P13866 | 4/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174274 | 0.88 | GCGR (0.42) | LIPECBLBSLC5A1PDE2A | |
| SCHEMBL6175934 | 0.88 | IGF1R (0.41) | CBLB | |
| SCHEMBL6175302 | 0.87 | GRM5 (0.45) | LIPECBLBSLC5A1 | |
| SCHEMBL6174034 | 0.87 | CBLB (0.36) | CBLBKDM4E | |
| SCHEMBL6171770 | 0.85 | LMNA (0.43) | CBLBLMNASLC5A1PDE2A | |
| SCHEMBL6173730 | 0.85 | IDH1 (0.42) | LMNA | |
| SCHEMBL6173626 | 0.84 | SLC5A1 (0.37) | CBLBLMNASLC5A1PDE2A | |
| SCHEMBL6177704 | 0.83 | KDR (0.42) | SLC5A1GSK3B | |
| SCHEMBL6177220 | 0.83 | LMNA (0.40) | LIPELMNASLC5A1PDE2A | |
| SCHEMBL6172737 | 0.83 | MAPK1 (0.37) | CBLBLMNAMAPTSLC5A1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |