Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.39 |
| ▸ | PDE2A | O00408 | 8/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177584 | 0.87 | IGF1R (0.38) | LMNAPDE2A | |
| SCHEMBL6174217 | 0.87 | IGF1R (0.38) | LMNA | |
| SCHEMBL6173730 | 0.85 | IDH1 (0.42) | LMNA | |
| SCHEMBL6174274 | 0.85 | GCGR (0.42) | PDE2ATRPV1LIPESLC5A1 | |
| SCHEMBL6171770 | 0.85 | LMNA (0.43) | LMNAPDE2ASLC5A1 | |
| SCHEMBL6172084 | 0.84 | LMNA (0.40) | LMNAPDE2ASLC5A1 | |
| SCHEMBL6175302 | 0.84 | GRM5 (0.45) | LIPESLC5A1 | |
| SCHEMBL6177007 | 0.83 | TDP1 (0.42) | LMNAPDE2ALIPESLC5A1 | |
| SCHEMBL6174848 | 0.82 | LMNA (0.46) | LMNAPDE2ALIPESLC5A1 | |
| SCHEMBL6175179 | 0.82 | ABL1 (0.44) | LMNATLR7PDE2ATRPV1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |