Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL27930467 | 0.90 | TSHR (0.60) | TSHRTHRBFFAR3HDAC3HDAC1 | |
| Succinic Acid SCHEMBL5426323 | 0.90 | THRB (0.61) | TSHRTHRBFFAR3HDAC3HDAC1 | |
| Acetic Acid SCHEMBL21001126 | 0.90 | TSHR (0.64) | TSHRTHRBTDP1POLBAPEX1 | |
| SCHEMBL16573 | 0.89 | — | — | |
| SCHEMBL21772349 | 0.89 | TSHR (0.69) | TSHRTHRBTDP1POLBAPEX1 | |
| Methacrylic Acid SCHEMBL932917 | 0.88 | TSHR (0.62) | TSHRTHRBTDP1POLBAPEX1 | |
| Methacrylic Acid SCHEMBL28367115 | 0.88 | TSHR (0.62) | TSHRTHRBTDP1POLBAPEX1 | |
| Succinic Acid SCHEMBL28866675 | 0.88 | THRB (0.53) | TSHRTHRBFFAR3HDAC3HDAC1 | |
| SCHEMBL1514196 | 0.87 | TSHR (0.67) | TSHRTHRBTDP1POLBAPEX1 | |
| Hydrogen Sulfide SCHEMBL6879353 | 0.87 | TSHR (0.67) | TSHRTHRBTDP1POLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1323784-B1 | Resin composition for coating optical fiber and coated optical fiber and optical fiber unit using the same | DAINIPPON INK & CHEMICALS (JP) | 2005-02-16 | — | — | EP | disclosed |
| US-6850682-B2 | Resin composition for coating optical fiber and coated optical fiber and optical fiber unit using the same | DAINIPPON INK AND CHEMICALS, INC. (JP) | 2005-02-01 | — | — | US | disclosed |
| US-20030138231-A1 | Resin composition for coating optical fiber and coated optical fiber and optical fiber unit using the same | DAINIPPON INK AND CHEMICALS, INC. (JP) | 2003-07-24 | — | — | US | disclosed |
| EP-1323784-A1 | Resin composition for coating optical fiber and coated optical fiber and optical fiber unit using the same | DAINIPPON INK AND CHEMICALS, INC. (JP) | 2003-07-02 | — | — | EP | disclosed |