Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 10/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173116 | 0.88 | KCNK2 (0.38) | ABL1GSK3BPOLBBRAFTEK | |
| SCHEMBL6172433 | 0.87 | GAA (0.38) | ABL1GSK3BPOLBBRAFGRM5 | |
| SCHEMBL6174987 | 0.87 | GAA (0.41) | ABL1GSK3AGSK3BPOLB | |
| SCHEMBL6277100 | 0.87 | GSK3A (0.38) | LIPEABL1GSK3AGSK3B | |
| SCHEMBL6177285 | 0.86 | TDP1 (0.42) | LIPEGSK3AGSK3B | |
| SCHEMBL6171763 | 0.85 | LMNA (0.38) | LIPEABL1GSK3AGSK3BPOLB | |
| SCHEMBL6176663 | 0.84 | LMNA (0.39) | ABL1GSK3AGSK3BPOLBNTRK1 | |
| SCHEMBL6174451 | 0.83 | LMNA (0.40) | LIPEABL1GSK3AGSK3B | |
| SCHEMBL6175302 | 0.83 | GRM5 (0.45) | LIPEABL1NTRK1BRAFGRM5 | |
| SCHEMBL6174779 | 0.83 | LMNA (0.36) | LIPEABL1GSK3AGSK3BPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |