Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.45 |
| ▸ | LIPE | Q05469 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | CBLB | Q13191 | 2/20 | 0.40 |
| ▸ | SLC5A1 | P13866 | 4/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174274 | 0.92 | GCGR (0.42) | LIPECBLBSLC5A1ABL1 | |
| SCHEMBL6175133 | 0.87 | GRM5 (0.43) | GRM5CBLBBRAFMAPK13MAPK12 | |
| SCHEMBL6177007 | 0.87 | TDP1 (0.42) | LIPECBLBSLC5A1 | |
| SCHEMBL6177220 | 0.84 | LMNA (0.40) | LIPESLC5A1 | |
| SCHEMBL6174788 | 0.83 | LMNA (0.38) | LIPESLC5A1ABL1 | |
| SCHEMBL6173626 | 0.83 | SLC5A1 (0.37) | NTRK1CBLBSLC5A1ABL1BRAF | |
| SCHEMBL6171770 | 0.83 | LMNA (0.43) | CBLBSLC5A1 | |
| SCHEMBL6173730 | 0.83 | IDH1 (0.42) | BRAF | |
| SCHEMBL6175153 | 0.83 | LIPE (0.43) | GRM5LIPENTRK1ABL1BRAF | |
| SCHEMBL6172737 | 0.82 | MAPK1 (0.37) | NTRK1CBLBSLC5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |