Sugi Predict

Sugi Predict / Compounds / SCHEMBL6174116

SCHEMBL6174116

SCHEMBL6174116

CC(c1ccncc1NS(N)(=O)=O)C1NC(=O)N(c2ccc(S(=O)(=O)C(F)(F)F)cc2)C1=O

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 2/20 0.33
▸ LMNA P02545 1/20 0.32
▸ PTGS2 P35354 2/20 0.32
▸ PTGS1 P23219 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6174557 0.90 IGF1R (0.33) IGF1RLMNAPTGS2PTGS1
SCHEMBL6176687 0.90 IGF1R (0.33) IGF1RLMNA
SCHEMBL6176021 0.89 IGF1R (0.34) IGF1RLMNAPTGS2PTGS1
SCHEMBL6175990 0.88 KIF11 (0.37) IGF1RLMNA
SCHEMBL6172477 0.87 IGF1R (0.35) IGF1RLMNA
SCHEMBL6173243 0.87 METAP2 (0.37) IGF1RLMNAPTGS2PTGS1
SCHEMBL6175175 0.86 IGF1R (0.36) IGF1RLMNAPTGS2
SCHEMBL6174151 0.84 NAMPT (0.35) IGF1RLMNAPTGS2PTGS1
SCHEMBL6171408 0.84 IGF1R (0.35) IGF1RLMNAPTGS2
SCHEMBL6174685 0.84 RXFP1 (0.36) IGF1RLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 — — EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 — — WO disclosed