Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.32 |
| ▸ | CCR9 | P51686 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | CMA1 | P23946 | 1/20 | 0.30 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174450 | 0.90 | IGF1R (0.38) | IGF1RRXFP1LMNA | |
| SCHEMBL6175260 | 0.88 | IGF1R (0.39) | IGF1RLMNAPTGS2HRH4SMN1; SMN2 | |
| SCHEMBL6175175 | 0.87 | IGF1R (0.36) | IGF1RLMNAPTGS2SMN1; SMN2MAPK1 | |
| SCHEMBL6174658 | 0.85 | RXFP1 (0.34) | IGF1RRXFP1LMNACA12CA1 | |
| SCHEMBL6171408 | 0.85 | IGF1R (0.35) | IGF1RLMNAPTGS2LARS1SMN1; SMN2 | |
| SCHEMBL6173330 | 0.84 | IGF1R (0.40) | IGF1RLMNASMN1; SMN2MAPK1HTT | |
| SCHEMBL6175529 | 0.83 | IGF1R (0.37) | IGF1RLMNAHRH4 | |
| SCHEMBL6176021 | 0.83 | IGF1R (0.34) | IGF1RRXFP1LMNAPTGS1PTGS2 | |
| SCHEMBL6175297 | 0.82 | LMNA (0.39) | IGF1RLMNAPTGS2SMN1; SMN2MAPK1 | |
| SCHEMBL6174116 | 0.81 | IGF1R (0.33) | IGF1RLMNAPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |