Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 3/20 | 0.39 |
| ▸ | CDK8 | P49336 | 3/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LIPE | Q05469 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | F2R | P25116 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | MC1R | Q01726 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173353 | 0.85 | LMNA (0.45) | LMNACXCR3KMT2ALIPEALDH1A1 | |
| SCHEMBL6170501 | 0.84 | LMNA (0.42) | LMNACXCR3LIPEMAPTPOLB | |
| SCHEMBL6174451 | 0.84 | LMNA (0.40) | LMNACXCR3LIPEALDH1A1F2R | |
| SCHEMBL6173172 | 0.82 | LMNA (0.41) | LMNAMAPTL3MBTL1 | |
| SCHEMBL6176359 | 0.81 | LMNA (0.39) | LMNACXCR3LIPEMAPTPOLB | |
| SCHEMBL6176663 | 0.81 | LMNA (0.39) | LMNACXCR3MAPTPOLBL3MBTL1 | |
| SCHEMBL6175831 | 0.81 | NPC1 (0.46) | LMNACCNCCDK8 | |
| SCHEMBL6173698 | 0.81 | LMNA (0.42) | LMNACXCR3LIPEPOLBL3MBTL1 | |
| SCHEMBL6171763 | 0.80 | LMNA (0.38) | LMNACXCR3LIPEMAPTPOLB | |
| SCHEMBL6173186 | 0.79 | LMNA (0.40) | LMNACXCR3LIPEMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |