Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CXCR3 | P49682 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LIPE | Q05469 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.33 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.33 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.33 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.33 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.33 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.33 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.33 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CCR6 | P51684 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170501 | 0.90 | LMNA (0.42) | LMNACXCR3POLBL3MBTL1LIPE | |
| SCHEMBL6172002 | 0.88 | LMNA (0.41) | LMNAKMT2AALDH1A1 | |
| SCHEMBL6176359 | 0.88 | LMNA (0.39) | LMNACXCR3POLBL3MBTL1LIPE | |
| SCHEMBL6173172 | 0.87 | LMNA (0.41) | LMNAL3MBTL1SMN1; SMN2TP53KCNH2 | |
| SCHEMBL6174458 | 0.87 | SLC5A1 (0.40) | LMNACXCR3POLBL3MBTL1LIPE | |
| SCHEMBL6175948 | 0.85 | LMNA (0.42) | LMNACXCR3POLBL3MBTL1LIPE | |
| SCHEMBL6175321 | 0.85 | KCNA5 (0.41) | LMNALIPESMN1; SMN2TP53KMT2A | |
| SCHEMBL6173052 | 0.83 | EPHX2 (0.36) | LMNACXCR3POLBL3MBTL1LIPE | |
| SCHEMBL6175577 | 0.82 | EPHX2 (0.40) | LMNALIPETP53ALDH1A1 | |
| SCHEMBL6176663 | 0.82 | LMNA (0.39) | LMNACXCR3POLBL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |