Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174291 | 0.72 | KDM4E (0.39) | OPRM1KDM4EALDH1A1GAAMAPT | |
| SCHEMBL7562120 | 0.71 | ALDH1A1 (0.31) | OPRK1OPRM1KDM4EALDH1A1GAA | |
| SCHEMBL6188998 | 0.69 | OPRD1 (0.34) | OPRK1OPRD1OPRM1SLC6A4SLC6A2 | |
| SCHEMBL6173540 | 0.69 | LDHA (0.40) | OPRK1OPRD1OPRM1SLC6A4SLC6A2 | |
| SCHEMBL27427537 | 0.68 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL7562332 | 0.68 | KDM4E (0.32) | OPRM1KDM4EALDH1A1GAAMAPT | |
| SCHEMBL18511473 | 0.64 | ESR1 (0.46) | OPRK1OPRD1OPRM1SLC6A4KDR | |
| SCHEMBL29377066 | 0.60 | ALDH1A1 (0.42) | OPRK1OPRD1OPRM1SLC6A4KDR | |
| SCHEMBL2506238 | 0.60 | ALDH1A1 (0.42) | OPRK1OPRD1OPRM1SLC6A4KDR | |
| SCHEMBL2498400 | 0.60 | ALDH1A1 (0.40) | SLC6A3KDM4EALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203770-B1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | UPJOHN CO (US) | 2005-03-09 | — | — | EP | disclosed |
| EP-0668860-B1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | UPJOHN CO (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1203770-A1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | PHARMACIA & UPJOHN COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-1994011361-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | THE UPJOHN COMPANY (US) | 1994-05-26 | — | — | WO | disclosed |