Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.30 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177593 | 0.79 | GABRA1 (0.50) | HPGDSMN1; SMN2CYP11B1CYP11B2PDE3B | |
| SCHEMBL30101524 | 0.79 | HPGD (0.31) | HPGDSMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL31299228 | 0.79 | KDM4E (0.41) | HPGDSMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL21521531 | 0.79 | HPGD (0.31) | HPGDSMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL26613699 | 0.77 | — | — | |
| SCHEMBL26613801 | 0.73 | MAOA (0.33) | HPGDSMN1; SMN2 | |
| SCHEMBL15273658 | 0.73 | HPGD (0.42) | HPGDSMN1; SMN2 | |
| SCHEMBL29760935 | 0.71 | — | — | |
| SCHEMBL1230178 | 0.71 | — | — | |
| SCHEMBL7259584 | 0.70 | LIPG (0.40) | HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |