Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A1 | P13866 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.41 |
| ▸ | ROS1 | P08922 | 6/20 | 0.41 |
| ▸ | KDR | P35968 | 5/20 | 0.41 |
| ▸ | BRAF | P15056 | 4/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175913 | 0.87 | IGF1R (0.54) | IGF1R | |
| SCHEMBL6172735 | 0.85 | IGF1R (0.42) | SLC5A1KDRIGF1R | |
| SCHEMBL6173624 | 0.84 | IGF1R (0.42) | KDRIGF1R | |
| SCHEMBL6172079 | 0.84 | IGF1R (0.47) | IGF1R | |
| SCHEMBL6175032 | 0.83 | MAPK1 (0.43) | BRAFGSK3BIGF1R | |
| SCHEMBL6174016 | 0.83 | IGF1R (0.41) | SLC5A1KDRIGF1R | |
| SCHEMBL6174271 | 0.83 | LMNA (0.43) | IGF1R | |
| SCHEMBL6173728 | 0.83 | MEN1 (0.47) | KDRBRAFIGF1R | |
| SCHEMBL6171765 | 0.83 | IGF1R (0.41) | SLC5A1KDRIGF1R | |
| SCHEMBL6177003 | 0.83 | TDP1 (0.42) | KDRBRAFGSK3BIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |