Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.41 |
| ▸ | FEN1 | P39748 | 2/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.40 |
| ▸ | HBB | P68871 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6182178 | 0.92 | KEAP1 (0.51) | KEAP1MEN1KMT2ABRAFMRGPRX4 | |
| Ethylene SCHEMBL6177711 | 0.90 | KEAP1 (0.49) | KEAP1MEN1KMT2ABRAFMRGPRX4 | |
| SCHEMBL387352 | 0.83 | MRGPRX4 (0.47) | BRAFMRGPRX4ADRB2ADRB1HTR1A | |
| SCHEMBL6176411 | 0.81 | MRGPRX4 (0.57) | BRAFMRGPRX4ALOX5APFEN1ADRB2 | |
| SCHEMBL6178803 | 0.81 | KEAP1 (0.57) | KEAP1MEN1KMT2ABRAFMRGPRX4 | |
| SCHEMBL6178724 | 0.81 | HSPB1 (0.49) | MEN1KMT2ABRAFMRGPRX4ADRB2 | |
| SCHEMBL6178192 | 0.79 | KEAP1 (0.57) | KEAP1MEN1KMT2ABRAFALOX5AP | |
| SCHEMBL6178588 | 0.76 | MRGPRX4 (0.46) | MEN1KMT2ABRAFMRGPRX4ADRB2 | |
| SCHEMBL385379 | 0.75 | NNMT (0.46) | BRAFMRGPRX4ABCB1 | |
| SCHEMBL6178103 | 0.74 | ALDH1A1 (0.47) | BRAFMRGPRX4ADRB2ADRB1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066261-B1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMA CO LTD (JP) | 2005-11-23 | — | — | EP | disclosed |
| US-6511995-B1 | Inhibits collagen synthesis, which is useful for prophylaxis or treatment of fibrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1066261-A1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999048871-A1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1999-09-30 | — | — | WO | disclosed |