Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 8/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178420 | 0.91 | HTR1A (0.54) | HTR1AMEN1KMT2ADRD2TSHR | |
| Cyclohexane SCHEMBL6180435 | 0.90 | MEN1 (0.48) | HTR1AMEN1KMT2ADRD2PROKR1 | |
| SCHEMBL7760241 | 0.85 | MEN1 (0.54) | HTR1AMEN1KMT2ADRD2DRD4 | |
| Cyclohexane SCHEMBL6178387 | 0.81 | MEN1 (0.48) | HTR1AMEN1KMT2ADRD2PROKR1 | |
| SCHEMBL6180428 | 0.78 | MEN1 (0.50) | MEN1KMT2ADRD2DRD4ATM | |
| SCHEMBL6181828 | 0.77 | MEN1 (0.45) | HTR1AMEN1KMT2ADRD2DRD4 | |
| SCHEMBL6181848 | 0.76 | MEN1 (0.55) | MEN1KMT2ADRD2DRD4HTR7 | |
| SCHEMBL6180433 | 0.75 | MEN1 (0.53) | MEN1KMT2ADRD2DRD4HTR7 | |
| SCHEMBL6178285 | 0.75 | MEN1 (0.55) | HTR1AMEN1KMT2ADRD2DRD4 | |
| SCHEMBL6180627 | 0.75 | DRD4 (0.51) | HTR1AMEN1KMT2ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140830-B1 | ARYLPIPERIDINE AND ARYL-1,2,5,6-TETRAHYDROPYRIDINE AMIDE DERIVATIVES HAVING 5HT1A RECEPTOR ACTIVITY | WYETH CORP (US) | 2005-05-04 | — | — | EP | claimed |
| US-20020035263-A1 | Novel arylpiperidine and aryl-1,2,5,6-tetrahydropyridine amide derivatives | AMERICAN HOME PRODUCTS CORPORATION | 2002-03-21 | — | — | US | claimed |
| US-6326381-B1 | PSYCHOLOGICAL DISORDERS; NERVOUS SYSTEM DISORDERS | AMERICAN HOME PRODUCTS CORPORATION | 2001-12-04 | — | — | US | claimed |
| EP-1140830-B1 | ARYLPIPERIDINE AND ARYL-1,2,5,6-TETRAHYDROPYRIDINE AMIDE DERIVATIVES HAVING 5HT1A RECEPTOR ACTIVITY | WYETH CORP (US) | 2005-05-04 | — | — | EP | disclosed |
| US-20020035263-A1 | Novel arylpiperidine and aryl-1,2,5,6-tetrahydropyridine amide derivatives | AMERICAN HOME PRODUCTS CORPORATION | 2002-03-21 | — | — | US | disclosed |
| US-6326381-B1 | PSYCHOLOGICAL DISORDERS; NERVOUS SYSTEM DISORDERS | AMERICAN HOME PRODUCTS CORPORATION | 2001-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020035263-A1 | Novel arylpiperidine and aryl-1,2,5,6-tetrahydropyridine amide derivatives | ADRA1D, ADH1C, HTR1D | HTR1A 11/4885MEN1 2956/4885KMT2A 945/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.