Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 4/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6181372 | 1.00 | HPGD (0.43) | HPGDBRAFABCB1CYP3A4CYP1A1 | |
| SCHEMBL6178308 | 1.00 | HPGD (0.43) | HPGDBRAFABCB1CYP3A4CYP1A1 | |
| SCHEMBL6178103 | 0.82 | ALDH1A1 (0.47) | HPGDBRAFABCB1MRGPRX4S1PR1 | |
| SCHEMBL6178442 | 0.81 | L3MBTL1 (0.42) | HPGDBRAFABCB1MRGPRX4MAPT | |
| SCHEMBL6181839 | 0.81 | L3MBTL1 (0.42) | HPGDBRAFABCB1MRGPRX4MAPT | |
| SCHEMBL6178436 | 0.81 | L3MBTL1 (0.42) | HPGDBRAFABCB1MRGPRX4MAPT | |
| Hydrochloric Acid SCHEMBL6179651 | 0.76 | KCNQ3 (0.51) | MAPTKMT2A | |
| SCHEMBL6176251 | 0.76 | NPC1 (0.47) | BRAFLMNAMAPTKMT2A | |
| SCHEMBL6182178 | 0.74 | KEAP1 (0.51) | HPGDBRAFABCB1MRGPRX4S1PR1 | |
| SCHEMBL6181815 | 0.73 | CDK8 (0.46) | BRAFCYP3A4CYP1A2CYP2D6MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066261-B1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMA CO LTD (JP) | 2005-11-23 | — | — | EP | disclosed |
| US-6511995-B1 | Inhibits collagen synthesis, which is useful for prophylaxis or treatment of fibrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1066261-A1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999048871-A1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1999-09-30 | — | — | WO | disclosed |