SCHEMBL6178413

SCHEMBL6178413

Cc1ccc2c(c1)N(CC(=O)c1cccs1)C(=O)C(N)CN2C(=O)C(C)(C)C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.40
TSHR P16473 3/20 0.38
CYP1A2 P05177 2/20 0.37
CYP2D6 P10635 2/20 0.37
CYP2C19 P33261 1/20 0.37
SMN1; SMN2 Q16637 4/20 0.36
MAPK1 P28482 1/20 0.36
NPC1 O15118 3/20 0.36
RAB9A P51151 3/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
LMNA P02545 1/20 0.35
HTT P42858 1/20 0.35
AADAT Q8N5Z0 1/20 0.34
GAA P10253 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
TP53 P04637 1/20 0.33
HPGD P15428 1/20 0.33
NFKB1 P19838 1/20 0.33
NFKB2 Q00653 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6180722 0.90 ALDH1A1 (0.47) ALDH1A1TSHRCYP1A2CYP2D6CYP2C19
SCHEMBL6175739 0.89 ALDH1A1 (0.39) ALDH1A1TSHRCYP1A2CYP2D6CYP2C19
SCHEMBL6209886 0.83 TSHR (0.35) ALDH1A1TSHRCYP1A2CYP2D6CYP2C19
SCHEMBL6176995 0.83 TSHR (0.40) ALDH1A1TSHRCYP1A2CYP2D6CYP2C19
SCHEMBL7962064 0.83 CCKBR (0.36) ALDH1A1TSHRCYP1A2CYP2D6CYP2C19
SCHEMBL7950890 0.81 HTT (0.38) ALDH1A1TSHRSMN1; SMN2MAPK1KMT2A
SCHEMBL6176322 0.81 TSHR (0.43) ALDH1A1TSHRCYP1A2CYP2D6CYP2C19
SCHEMBL6177943 0.80 TSHR (0.34) ALDH1A1TSHRCYP1A2CYP2D6CYP2C19
SCHEMBL6176746 0.78 CCKBR (0.52)
SCHEMBL6177998 0.77 CCKBR (0.47) MAPK1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0945445-B9 1,5-BENZODIAZEPINE DERIVATIVES ZERIA PHARM CO LTD (JP) 2005-12-28 EP disclosed
EP-0945445-B1 1,5-BENZODIAZEPINE DERIVATIVES ZERIA PHARM CO LTD (JP) 2003-09-03 EP disclosed
US-6239131-B1 WHICH HAVE GASTRIN AND/OR CCK-B (CHOLECYSTOKININ-B) RECEPTOR ANTAGONISM, USEFUL AS REMEDIES FOR GASTRIC ULCER AND GASTROINTESTINAL MOVEMENT DISORDER. ZERIA PHARMACEUTICAL CO., LTD. (JP) 2001-05-29 US disclosed
EP-0945445-A1 1,5-BENZODIAZEPINE DERIVATIVES ZERIA PHARMACEUTICAL CO., LTD. (JP) 1999-09-29 EP disclosed