Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.43 |
| ▸ | UBA2 | Q9UBT2 | 2/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6180795 | 0.91 | MAPT (0.47) | MAPTNPC1SAE1UBA2RAF1 | |
| SCHEMBL6179603 | 0.84 | CDK8 (0.44) | MAPTNPC1RAB9AHTR2CHTR2A | |
| SCHEMBL6178759 | 0.83 | RAB9A (0.52) | MAPTNPC1RAF1RAB9AL3MBTL1 | |
| SCHEMBL6178821 | 0.82 | RAB9A (0.49) | MAPTNPC1RAF1RAB9AL3MBTL1 | |
| SCHEMBL6178810 | 0.82 | KDR (0.46) | MAPTNPC1SAE1UBA2RAF1 | |
| SCHEMBL6181402 | 0.82 | MAPT (0.49) | MAPTNPC1SAE1UBA2RAF1 | |
| SCHEMBL6178666 | 0.80 | MAPT (0.49) | MAPTNPC1SAE1UBA2RAF1 | |
| SCHEMBL6180084 | 0.79 | KEAP1 (0.44) | RAB9AHTR2CHTR2BKDM4EMEN1 | |
| SCHEMBL6179531 | 0.78 | KCNQ3 (0.45) | MAPTNPC1RAB9AL3MBTL1GAA | |
| SCHEMBL6176705 | 0.76 | CDK8 (0.45) | MAPTNPC1RAB9AHTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066261-B1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMA CO LTD (JP) | 2005-11-23 | — | — | EP | disclosed |
| US-6511995-B1 | Inhibits collagen synthesis, which is useful for prophylaxis or treatment of fibrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |